Structure–activity relationship of carbamate-linked cationic lipids bearing hydroxyethyl headgroup for gene delivery

Defu Zhi,Shubiao Zhang,Farooq Qureshi,Yinan Zhao,Shaohui Cui,Bing Wang,Huiying Chen,Baoling Yang,Defeng Zhao

Colloids and Surfaces B: Biointerfaces（2013）

Cited 11|Views11

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Abstract

•Three new carbamate-linked cationic lipids with hydroxyl headgroup were synthesized.•These lipids are easy to produce starting from environmentally friendly materials.•These liposomes exhibit relatively high transfection efficiency and low toxicity.•The inclusion of hydroxyl group in the headgroup can improve transfection efficiency.

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Key words

Carbamate-linked cationic lipids,Hydroxyl group,Gene delivery,Transfection efficiency,Cytotoxicity

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