Expression and significance of microRNA-183 in hepatocellular carcinoma.
SCIENTIFIC WORLD JOURNAL(2013)
Abstract
Objective. In our previous study, we found that some miRNAs were deregulated in hepatocellular carcinoma (HCC), including miR183. However, the expression of miR-183 in the progression of benign liver diseases toHCCand its correlation with clinicopathologic factors remain undefined. Methods. MiR-183 expression was measured in normal controls (NC) (n = 21), chronic viral hepatitis B or C (CH) tissues (n = 10), liver cirrhosis (LC) tissues (n = 18), HCC tissues (n = 92), and adjacent nontumor tissues (NT) (n = 92) by quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR). Results. The expression levels of miR-183 were significantly higher in HCC than in NT, LC, CH, and NL (n = 0.001,n < 0.001,n = 0.011,n < 0.001, resp.). The upregulated miR-183 in HCC was correlated with TNM stage (n = 0.042) and cirrhosis (n = 0.025). The Kaplan-Meier survival analysis showed that miR-183 expression was not associated with the survival of HCC patients. However, miR-183 yielded an area under the curve (AUC) of 0.808 with 59.8% sensitivity and 91.8% specificity in discriminating HCC frombenign liver diseases (CH and LC) or NC. Conclusions. The upregulated miR-183 may associate with onset and progression of HCC, but not with the patient survival. A further research is needed to determine the potential of miR-183 as biomarker for HCC.
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Key words
micrornas,case control studies,up regulation
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