PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity.

•First time to display that LPS downregulate the expression of PRC.•First time to show that PRC inhibits the induction of VCAM-1 and E-selectin.•First time to show that PRC inhibit monocytes attachment to endothelial cells.•First time to display that PRC inhibits transcriptional activity of NF-κB.•PRC protects the respiration rate and suppresses the glycolysis rate against LPS.