Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA
Journal of Translational Medicine(2013)
Abstract
The naked caspase-3 small interfering RNA (siRNA) infused into the renal artery during cold preservation was effective, but did not protect auto-transplant porcine kidneys with increased inflammation and apoptosis in our previous study. The mechanisms involved, in particular, whether siRNA or complementary systemic feedback eliciting innate immune responses are worthy to be further investigated.
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Key words
Small interfering RNA,Innate immunity,Toll like receptor,PKR,Porcine kidney auto-transplantation,Ischemia reperfusion injury
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