CD147 mediates chemoresistance in breast cancer via ABCG2 by affecting its cellular localization and dimerization.

•CD147 regulates ABCG2 protein expression and function in breast cancer cells.•CD147 influences ABCG2’s cellular location and dimerization.•CD147 and ABCG2 have significant correlation in breast invasive ductal cancer.•Both protein expressions are higher in chemotherapy-resistant group.•CD147 can mediate chemoresistance via ABCG2.