Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT1R in the rat aorta

•Pinocembrin inhibits AngII-induced contraction of rat aortic rings.•Pinocembrin displays noncompetitive antagonism of AngII-induced contractions.•Pinocembrin shows effective binding at the active site of AT1R in a docking model.•Blockade of [Ca2+]i increase and ERK1/2 activation contributes to the inhibition.•Pinocembrin inhibits AngII-induced vasoconstriction via AngII-AT1R-Ca2+-ERK pathway.