Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB.

Yongzhi Yang,Yanlei Ma,Chenzhang Shi,Hongqi Chen,Huizhen Zhang,Niwei Chen,Peng Zhang,Feng Wang,Jun Yang,Jianjun Yang,Qingchao Zhu,Yong Liang,Wen Wu,Renyuan Gao,Zhe Yang,Yang Zou, Huanlong Qin

Biochemical and Biophysical Research Communications（2013）

引用 126|浏览45

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摘要

•Both the mucosal and serum levels of miR-21 were upregulated in UC.•Overexpression of miR-21 impaired the integrity of the tight junctions.•miR-21 induced the depletion of RhoB and the impairment of the tight junctions.

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关键词

Ulcerative colitis,miR-21,Intestinal epithelial barrier,RhoB

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