Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells.
Biochemical and Biophysical Research Communications（2013）
Abstract
• Chidamide causes growth arrest of pancreatic cancer cells. • Chidamide synergistically enhances gemcitabine cytotoxicity against pancreatic cancer cells. • Chidamide and gemcitabine cooperate in inducing DNA double-strand breaks. • Chidamide suppresses the expression of CHK1 in pancreatic cancer cells.
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Key words
Chidamide,Pancreatic cancer,Gemcitabine,Apoptosis,DNA damage
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