Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Kyriaki Michailidou,Per Hall,Anna Gonzalez-Neira,Maya Ghoussaini,Joe Dennis,Roger L Milne,Marjanka K Schmidt,Jenny Chang-Claude,Stig E Bojesen,Manjeet K Bolla,Qin Wang,Ed Dicks,Andrew Lee,Clare Turnbull,Nazneen Rahman,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos Santos Silva,Heli Nevanlinna,Taru A Muranen,Kristiina Aittomäki,Carl Blomqvist,Kamila Czene,Astrid Irwanto,Jianjun Liu,Quinten Waisfisz,Hanne Meijers-Heijboer, Muriel Adank,Rob B van der Luijt,Rebecca Hein,Norbert Dahmen,Lars Beckman, Alfons Meindl,Rita K Schmutzler,Bertram Müller-Myhsok,Peter Lichtner,John L Hopper,Melissa C Southey,Enes Makalic,Daniel F Schmidt, Andre G Uitterlinden,Albert Hofman,David J Hunter,Stephen J Chanock,Daniel Vincent,François Bacot,Daniel C Tessier,Sander Canisius,Lodewyk F A Wessels,Christopher A Haiman,Mitul Shah,Robert Luben,Judith Brown,Craig Luccarini,Nils Schoof,Keith Humphreys,Jingmei Li,Børge G Nordestgaard,Sune F Nielsen,Henrik Flyger,Fergus J Couch,Xianshu Wang,Celine Vachon,Kristen N Stevens,Diether Lambrechts,Matthieu Moisse,Robert Paridaens,Marie-Rose Christiaens, Anja Rudolph,Stefan Nickels, Dieter Flesch-Janys,Nichola Johnson,Zoe Aitken,Kirsimari Aaltonen,Tuomas Heikkinen,Annegien Broeks,Laura J Van't Veer,C Ellen van der Schoot,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Frederik Marme,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,M Pilar Zamora,Jose Ignacio Arias Perez,Guillermo Pita,M Rosario Alonso,Angela Cox,Ian W Brock,Simon S Cross,Malcolm W R Reed,Elinor J Sawyer,Ian Tomlinson,Michael J Kerin,Nicola Miller,Brian E Henderson,Fredrick Schumacher,Loic Le Marchand,Irene L Andrulis, Julia A Knight,Gord Glendon,Anna Marie Mulligan,Annika Lindblom,Sara Margolin,Maartje J Hooning,Antoinette Hollestelle,Ans M W van den Ouweland,Agnes Jager,Quang M Bui,Jennifer Stone,Gillian S Dite,Carmel Apicella,Helen Tsimiklis,Graham G Giles,Gianluca Severi,Laura Baglietto, Peter A Fasching,Lothar Haeberle,Arif B Ekici,Matthias W Beckmann, Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Anthony Swerdlow,Alan Ashworth,Nick Orr,Michael Jones,Jonine Figueroa,Jolanta Lissowska,Louise Brinton,Mark S Goldberg,France Labrèche,Martine Dumont,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Bernardo Bonanni,Peter Devilee,Rob A E M Tollenaar,Caroline Seynaeve,Christi J van Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Katarzyna Durda,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M Hartikainen,Natalia V Bogdanova,Natalia N Antonenkova,Thilo Dörk,Vessela N Kristensen,Hoda Anton-Culver,Susan Slager,Amanda E Toland,Stephen Edge,Florentia Fostira,Daehee Kang,Keun-Young Yoo,Dong-Young Noh,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Aiko Sueta,Anna H Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O Stram,Xiao-Ou Shu, Wei Lu,Yu-Tang Gao,Hui Cai,Soo Hwang Teo,Cheng Har Yip,Sze Yee Phuah,Belinda K Cornes,Mikael Hartman,Hui Miao,Wei Yen Lim,Jen-Hwei Sng,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Chen-Yang Shen,Chia-Ni Hsiung,Pei-Ei Wu,Shian-Ling Ding,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,William J Blot,Lisa B Signorello,Qiuyin Cai,Wei Zheng,Sandra Deming-Halverson,Martha Shrubsole,Jirong Long,Jacques Simard,Montse Garcia-Closas,Paul D P Pharoah,Georgia Chenevix-Trench,Alison M Dunning,Javier Benitez,Douglas F Easton

Nature Genetics（2013）

引用 1266|浏览124

暂无评分

摘要

Douglas Easton, Per Hall and colleagues report meta-analyses of genome-wide association studies for breast cancer, including 10,052 cases and 12,575 controls, followed by genotyping using the iCOGS array in an additional 52,675 cases and 49,436 controls from studies within the Breast Cancer Association Consortium (BCAC). They identify 41 loci newly associated with susceptibility to breast cancer.

查看译文

关键词

Breast cancer,Genetic predisposition to disease,Genome-wide association studies,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要