BCR-ABL tyrosine kinase inhibitor pharmacophore model derived from a series of phenylaminopyrimidine-based (PAP) derivatives.

Jing Cui,Rao Fu,Li-Hua Zhou,Sheng-Ping Chen,Guang-Wu Li,Shen-Xian Qian,Shu Liu

Bioorganic & Medicinal Chemistry Letters（2013）

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摘要

Based on a series of phenylaminopyrimidinebased (PAP) derivatives that can inhibit BCR-ABL tyrosine kinase, a seven-point pharmacophore model was developed using Phase software. A statistically significant 3D-QSAR model was also yielded based on this pharmacophore model.

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关键词

BCR-ABL tyrosine kinase,3D-QSAR,Pharmacophore,Phase

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