Unusual spirodecane sesquiterpenes and a fumagillol analogue from cordyceps ophioglossoides

Investigation of the cultured mycelia of Cordyceps ophioglossoides resulted in the isolation and characterization of three new unusual spiro[4.5]decane sesquiterpenes, cordycepol A (1), cordycepol B (2), and cordycepol C (3), and a new fumagillol analogue, cordycol (4). Their structures were established by spectroscopic means. The cytotoxic activities were also evaluated, compounds 3 and 4 showing their IC50 values in the range of 1233 mu g/ml against HeLa and HepG2 (Table 3). In addition, 3 and 4 were not obviously harmful towards normal liver cell lines LO2, showing IC50 values above 80 mu g/ml.