Two new monoterpenes from Tithonia diversifolia and their anti-hyperglycemic activity
RECORDS OF NATURAL PRODUCTS(2013)
Abstract
Two new monoterpenes: ((1S,2R,3R,5S)-2-hydroxymethyl-6,6-dimethylbicyclo[3.1.1]heptane-2,3-diol (1) and (3R)-6,6-dimethyl-4-methylenebicyclo[3.1.1]heptane-1,3-diol-3-O-beta-D-glucopyranoside (2), along with three known compounds, namely, sobrerol (3), (1R,2S,5S)-2,8-p-menth-diol (4) and (1R,5S)-10-hydroxyverbenon (5), were isolated from aerial part of Tithonia diversifolia. Their structures were determined on the basis of spectroscopic analyses (IR, HR-ESI-MS/MS, 1D/2D NMR). Under the concentration of 10 mu g/mL, compounds 1 and 3 significantly increased glucose uptake in 3T3-L1 adipocytes without significant toxic effects in vitro.
MoreTranslated text
Key words
Tithonia diversifolia,Monoterpene,3T3-L1 adipocytes,Anti-hyperglycemic activity
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined