The Genetic Variant On Chromosome 10p14 Is Associated With Risk Of Colorectal Cancer: Results From A Case-Control Study And A Meta-Analysis

Background: A common single nucleotide polymorphism (SNP), rs10795668, located at 10p14, was first identified to be significantly associated with risk of colorectal cancer (CRC) by a genome-wide association study (GWAS) in 2008; however, another GWAS and following replication studies yielded conflicting results.Methods: We conducted a case-control study of 470 cases and 475 controls in a Chinese population and then performed a meta-analysis, integrating the current study and 9 publications to evaluate the association between rs10795668 and CRC risk. Heterogeneity among studies and publication bias were assessed by the chi(2)-based Q statistic test and Egger's test, respectively.Results: In the case-control study, significant association between the SNP and CRC risk was observed, with per-A-allele OR of 0.71 (95% CI: 0.54-0.94, P = 0.017). The following meta-analysis further confirmed the significant association, with per-A-allele OR of 0.91 (95% CI: 0.89-0.93, P-heterogeneity<0.05) in European population and 0.86 (95% CI: 0.78-0.96, P-heterogeneity>0.05) in Asian population. Besides, sensitivity analyses and publication bias assessment indicated the robust stability and reliability of the results.Conclusions: Results from our case-control study and the followed meta-analysis confirmed the significant association of rs10795668 with CRC risk.