Rapid and sensitive fluorescent probes for monoamine oxidases B to A at low concentrations

Yexiang Zhang,Yufang Xu,Shaoying Tan,Lin Xu,Xuhong Qian

Tetrahedron Letters（2012）

Cited 15|Views4

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Abstract

A new monoamine oxidase (MAO) fluorescent probe that displays response for both monoamine oxidase type-A (MAO-A) and monoamine oxidase type-B (MAO-B) is reported. This sensing platform does not require any additional enzymes or reagents. Furthermore, the probes have better sensitivity and shorter response time by comparison with similar probes, and have potentials in differentiation of MAO-A and MAO-B upon further optimization.

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Key words

Fluorescent probes,Monoamine oxidase type-B,Coumarin derivatives,Low concentrations

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