Abiestetranes A and B, two unique tetraterpenes from Abies fabri
Tetrahedron（2012）
Abstract
Abiestetranes A (1) and B (2), two unique tetraterpenes formed by Diels–Alder cycloaddition between a lanostane triterpenoid and a monoterpenoid, were isolated from Abies fabri. Their structures were elucidated by extensive analysis of NMR data. The electronic circular dichroism was utilized to assign the absolute configuration of 1. Compounds 1 and 2 showed significant cytotoxic activities against ZR-75-30 tumor cell with IC50 values of 6.26 and 1.63μg/mL, respectively.
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Key words
Abies fabri,Pinaceae,Diels–Alder cycloaddition,Tetraterpenes,Abiestetranes A and B,Cytotoxicity
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