Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors.

Bioorganic & Medicinal Chemistry（2012）

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摘要

Compound 8g (R′=H, R=2,4-dimethyl) more potently reversed P-gp-mediated MDR and persisted longer time than verapamil.

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关键词

P-gp inhibitor,Bifendate,Chalcone,Multidrug resistance,Cancer chemotherapy

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