Synthesis and biological evaluation of berberine derivatives as IBS modulator
LETTERS IN DRUG DESIGN & DISCOVERY（2012）
Abstract
Irritable bowel syndrome is the most common functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort in association with a change in bowel habit. 5-HT receptor modulators have been developed as IBS therapeutic agents and proved to be effective in the treatment of the disease. In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy.
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Key words
5-hydroxytryptamine,5-hydroxytryptamine receptor modulators,Berberine,Derivatives,Gastrointestinal disorder,Irritable bowel syndrome
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