Design and synthesis of novel β-diketo derivatives as HIV-1 integrase inhibitors.

Liming Hu,Sulei Zhang,Xianzhuo He,Zaigang Luo,Xiaoli Wang,Wei Liu,Xuemei Qin

Bioorganic & Medicinal Chemistry（2012）

引用 30|浏览1

暂无评分

摘要

A series of novel β-diketo derivatives which combined the virtues of 1,3-diketo, 1,2,3-triazole and polyhydroxylated aromatics moieties were prepared and their HIV-1 IN inhibitory activities were evaluated. The polyhydroxylated aromatic moiety plays an important role in the inhibitory of HIV integrase.

查看译文

关键词

HIV-1 Integrase,Inhibitor,1,3-Diketo,Polyhydroxylated aromatics,Strand transfer

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要