Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization.
Neuroscience(2012)
摘要
Class A scavenger receptor (SR-A) is primarily expressed in microglia/macrophages and plays an important role in immune responses. However, whether SR-A can influence microglia/macrophage polarization in cerebral ischemic injury is not known. To this end we monitored the phenotypic alteration of microglia/macrophages in an animal model of cerebral ischemia injury. SR-A was up-regulated in mouse brains 24h after permanent occlusion of middle cerebral artery (MCAO). SR-A-deficient mice displayed reduced infarct size and improved neurological function compared with wild-type mice littermate controls. Furthermore, a decrease in inflammatory F4/80+CD11b+CD45highCD11c+ microglia/macrophages and attenuated nuclear factor-kappaB (NF-κB) activation was found in ischemic brains in the SR-A null mice. This was accompanied by alleviation of classically activated M1 macrophage markers and preservation of alternatively activated M2 macrophage markers. These data suggest that SR-A contributes to cerebral ischemic injury by pivoting the phenotype of microglia/macrophages to a skewed M1 polarization.
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关键词
Aβ,CBF,EDTA,FBS,HRP,IFN-γ,iNOS,IL,LPS,MCAO,MCP-1,NF-κB,PCR,PBS,PDTC,RIPA,SR-A,TNF-α,TTC
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