Prevalence And Risk Factors Of Prolonged Qtc Interval Among Chinese Patients With Type 2 Diabetes

Objectives. The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes. Methods. The retrospective study included 3156 outpatients from the Diabetes Centre, the 306th Hospital of PLA, during the period from September 2003 to June 2010. QT interval was measured manually in the 12-lead conventional electrocardiogram. The QT interval corrected for heart rate (QTc) was calculated using Bazett's formula. Additional demographic and laboratory data were also collected. Potential risk factors of prolonged QTc interval were assessed using multivariable regression. Results. The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes was 30.1%. Height (OR 0.156, 95% CI 0.032 similar to 0.748), waist circumference (OR 1.025, 95% CI 1.010 similar to 1.040), diastolic blood pressure (OR 1.016, 95% CI 1.007 similar to 1.026), postprandial glucose (OR 1.040, 95% CI 1.022 similar to 1.059), fasting insulin (OR 1.014, 95% CI 1.003 similar to 1.025), and presence of microalbuminuria (OR 1.266, 95% CI 1.033 similar to 1.551) were significant risk factors. Conclusions. The prevalence of prolonged QTc interval among Chinese patients with type 2 diabetes is high. Risk factors for prolongation of QTc interval were low height, high waist circumference, increasing diastolic blood pressure levels, high postprandial glucose levels, high fasting insulin levels, and presence of microalbuminuria.