Expression of peroxiredoxin 6 in gastric cancer and its clinical significance]

To elucidate the significance of anti-oxidant protein peroxiredoxin 6 (Prx6) expression in gastric cancer (GC) tissue.Eighty-six GC tissues and 69 para-cancer tissues from surgically resected specimens were included. And the clinico-pathological data were collected by reviewing medical records. Tissue microarray and immunohistochemistry (IHC) were used to detect Prx6 protein expression in tissues.Prx6 protein was predominantly expressed in cytoplasm. Its expression rate in GC tissues (32.6%, n = 28) was significantly lower than that in para-cancer normal tissues (94.2%, n = 65, P < 0.05). And its protein overexpression rate in well and moderately-differentiated GC tissues was significantly higher than that in lowly-differentiated ones (39.6% (21/53) vs 6.1% (2/33), P < 0.05). Prx6 expression in gastric cancer tissues was not significantly related to age and sex of patients, lesion site, depth of invasion, clinical staging, vascular invasion and liver metastasis.The level of Prx6 protein is lower in GC tissues than that in normal para-cancer ones. And it is significantly correlated with the differentiation degree of GC.