Clinical Parameters For Prediction Of Successful Labor Induction After Application Of Intravaginal Dinoprostone In Nulliparous Chinese Women

Background: The aim of this study was to compare the possible clinical parameters for prediction of successful labor induction in Chinese nulliparous women.Material/Methods: A retrospective, observational trial of labor induction was performed, using a single dose of 10 mg controlled-release dinoprostone for preinduction cervical ripening in 127 nulliparous women (gestational age 38-42 weeks, singleton cephalic presentation). The characteristics of the women with successful labor induction (defined as vaginal delivery achieved on the day of admission; n=80) and failed labor induction (n=47) were compared.Results: The main differences observed between the groups were gravidity (P<0.05), induction-active labor interval (5.16 +/- 2.98 vs. 8.40 +/- 3.41; P<0.05) and birth weight (3421.11 +/- 368.14 vs. 3566.36 +/- 345.16; P<0.05). Logistic regression demonstrated that gravidity (P<0.05) and induction-active labor interval (P<0.05), but not Bishop score, were significant and independent contributing factors for successful labor induction. In the receiver operating characteristic curves for the prediction of successful labor induction, the best cut-off value for gravidity was 3 (95% confidence interval [CI] 0.64-0.83, P=0.000), and the best cut-off value for the induction-active labor interval was 7.96 (95% CI 0.66-0.85, P=0.000).Conclusions: Less gravidity and shorter induction-active labor interval predict successful labor induction with reasonable accuracy.