Two New Sesquiterpene Lactones From The Supercritical Fluid Extract Of Centipeda Minima
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH(2012)
Abstract
Two new sesquiterpene lactones, minimolides G (1) and H (2), were isolated from the supercritical fluid extract of Centipeda minima. Their structures were elucidated on the basis of extensive analyses of spectroscopic data including IR, HR-ESI-MS, 1D and 2D NMR. Compounds 1 and 2 displayed inhibitory activity against human nasopharyngeal cancer cell line (CNE) with IC50 values of 61.4 and 28.7 mu M, respectively.
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Key words
Centipeda minima,sesquiterpene lactones,supercritical fluid extract,antiproliferative activity
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