尿毒清颗粒灌肠对糖尿病肾病腹膜透析患者VEGF活性、炎症因子影响
Chinese Journal of Integrated Traditional and Western Nephrology(2013)
Abstract
目的:通过临床随机对照试验探讨腹膜透析患者应用尿毒清颗粒(尿毒清2袋水煎150ml)灌肠后对血管内皮细胞生长因子(VEGF)、炎症因子活性的影响。方法:试验对象为在我院行持续不卧床腹膜透析1个月以上的糖尿病肾病患者52例,按随机表法分成两组:尿毒清组及对照组,分别测试用药前及用药1个月后患者血清及透出液VEGF活性、血清炎症因子的变化。结果:(1)尿毒清组用药后血清及透出液VEGF活性均较用药前降低,差异有统计学意义(P<0.01);(2)尿毒清组用药后炎症因子较用药前降低,差异有统计学意义(P<0.05);(3)尿毒清组用药后血清及透出液VEGF活性较对照组降低,差异有统计学意义(P<0.05)。结论:(1)尿毒清颗粒能降低腹膜透析患者血清及透出液中VEGF活性及炎症因子浓度;(2)尿毒清颗粒可改善微炎症状态。
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