布鲁菌病活疫苗菌体高密度发酵工艺研究
Animal Husbandry and Feed Science(2012)
Abstract
在GMP原则的指导下,为了提高布鲁菌病活疫苗的产量和头份数,在500L发酵罐基础上,对布鲁菌S2株的菌体高密度发酵工艺进行了一系列优化试验,各项发酵培养条件经优化后,菌体的密度得到了明显提高,发酵菌数可达到300亿CFU/mL以上。
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