sICAM-1的表达在实验性重症急性胰腺炎肺损伤中的作用
Seek Medical and Ask the Medicine(2011)
Abstract
目的观察血清可溶性细胞间粘附分子-1(sICAM-1)的水平变化与重症急性胰腺炎(SAP)肺损伤(ALI)的关系,并观察二硫代氨基甲酸吡(pyrrolidine dithiocarbamate,PDTC)对SAP ALI的保护作用。方法对SD大鼠采用逆行胰胆管注射5%牛磺胆酸钠(0.1ml/100g)的方法制作SAP模型和PDTC干扰组模型,取3h、6h、9h、12h不同时点的血清进行sICAM-1检测,同时检测血清淀粉酶的浓度。结果制模3h后,血清sICAM-1的水平开始持续上升,肺部组织损伤程度逐渐加重,且血清淀粉酶浓度持续上升,血清sICAM-1与血清淀粉酶的水平之间有相关性。PDTC干预组血清sICAM-1的水平较低,肺部损伤也较轻。结论重症急性胰腺炎肺损伤时血清sICAM-1的水平变化与肺部损伤程度密切相关。
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