Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria.

Olalere Shittu,Olufunke Adenike Opeyemi,Olumuyiwa Babagbemi Omotesho,Oluwatosin Fakayode,Nnaemeka Asogwa,Opeyemi Margaret Adeniyi, Ifeoluwa Margaret Fatoba,Kayode Muritala Salawu,Olusola Ajibaye,Olarewaju Abdulkareem Babamale,Oluyinka Ajibola Iyiola,Olusola Isaac Aremu

Acta medica (Hradec Kralove)（2020）

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摘要

A remarkable inter-ethnic differences in autosomal recessive CYP2C8*2 allele was observed. By implication, there is a gradual incursion of genetic drift for poor CQ and AQ-Artemisinin metabolizers among the inhabitants.

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关键词

Amodiaquine-Artemisinin combination therapy,CYP2C8*2,Chloroquine,Hausa,Igbo,Nigeria,Plasmodium falciparum,Yoruba

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