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罗格列酮对肾间质损伤的保护作用及其机制

林沁,顾勇,马骥,林善锬

Journal of Fuzhou General Hospital（2011）

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Abstract
<正>前言肾间质纤维化的病理为多种细胞外基质(ECM)成分的积聚。大量体内和体外实验发现,多种细胞因子和生长因子与ECM合成及代谢的调节密切相关,参与了肾间质纤维化的发展过程,其中转化生长因子β1(TGF-β1)的地位尤为突出,被认为是所有进行性肾脏纤维化疾病中导致
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