诱导实验性肌炎模型并观察调节性T细胞的表达及意义

Chinese Journal of Cellular and Molecular Immunology(2011)

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Abstract
目的:观察实验性自身免疫性肌炎(EAM)小鼠脾细胞中调节性T细胞(Tregs)表达情况,并探讨相关免疫学机制。方法:雌性BALB/c小鼠随机分为肌球蛋白免疫的EAM模型组和生理盐水对照组,采用苏木精-伊红染色(HE)进行组织病理学评分,使用流式细胞术(FCM)检测小鼠脾细胞中CD4+CD25+Foxp3+Treg细胞表达比例。结果:EAM模型组小鼠肌组织出现大量炎细胞浸润;FCM检测EAM模型组小鼠脾细胞中CD4+CD25+Foxp3+Treg较对照组明显升高(P<0.01)。结论:CD4+CD25+Foxp3+Treg参与调控EAM的病理过程。
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