抗凋亡基因Bcl-xl与缺血性脑血管病
Journal of Clinical Neurology(2010)
Abstract
大脑短暂缺血后,缺血中心区域的神经细胞很快出现坏死,而缺血半暗带却要经过1~2 d的潜伏期后,才会发生延迟性神经元退变.这种延迟性神经元退变即细胞凋亡,是由促凋亡基因(如p53、caspase)和抗凋亡基因(如Bcl-2、c-fos、c-jun)等参与调控的.
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