汉方抗痘凝胶制备工艺研究
Chinese Journal of Experimental Traditional Medical Formulae(2009)
Abstract
目的:筛选以中药汉方为组方依据的抗痘凝胶的最佳制备工艺。方法:采用L933正交设计,以黄芩苷含量和抑菌效果为指标,筛选最佳提取工艺;通过HPLC法测定透皮实验中药物透过大鼠皮到达接收液中黄芩苷的含量,以其为指标采用L923正交设计筛选汉方抗痘凝胶剂渗透促进剂用量。结果:最佳提取工艺:10倍量60%乙醇,提取2次,每次1.5h;卡波姆为凝胶基质,35%的丙二醇和2%的氮酮为渗透促进剂制备抗痘凝胶。结论:该优选制备工艺稳定合理。
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