胆固醇酯转运蛋白基因多态性与他汀类药的调脂效应
South China Journal of Cardiovascular Diseases(2007)
Abstract
提要:胆固醇酯转运蛋白作为参与细胞胆固醇代谢过程的一个关键成员,其基因的某些单核苷酸多态如TaqIB,I405V,-629C/A,-631C/A,-971G/A等能影响他汀类药对心血管疾病患者血清胆固醇水平的调节作用。表明胆固醇酯转运蛋白基因单核苷酸多态性可能影响他汀类药的调脂效果及冠心病的疗效。
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