急性颅脑损伤患者IGF-1动态变化的临床意义
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine（2007）
Abstract
目的:了解急性颅脑损伤患者血清胰岛素样生长因子-1(IGF-1)水平的动态变化及其临床意义。方法:采用放免法测定40例颅脑损伤患者(脑外伤组)起病后2天内、2周时血清IGF-1的含量,并与20例健康人(对照组)比较。结果:起病2天内颅脑损伤患者血清IGF-1水平明显低于对照组,差异有显著性意义(P<0.01),2周时血清IGF-1水平有恢复。结论:颅脑损伤患者急性期血清IGF-1浓度明显降低,颅脑损伤患者急性期血清IGF-1水平可帮助判断病情轻重和预后。IGF-1也许能通过血脑屏障产生神经保护,具有潜在的临床价值。
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