耦联因子-6与高血压及其并发症的研究进展
Chinese Journal of Difficult and Complicated Cases（2007）
Abstract
1998年Osanai等[1]首次从自发性高血压大鼠(SHR)心、肝、肾等组织中提取纯化出一种能抑制前列环素2(prostacyclin 2,PGI2)生成的活性物质,发现了耦联因子-6(coupling factor 6,CF-6).CF-6是线粒体ATP合酶的一个亚单位,是迄今发现的体内惟一的内源性PGI2合成抑制因子.
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