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培美曲塞及其在消化道肿瘤中应用研究进展

金时代,刘平

Chinese Clinical Oncology（2007）

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Abstract
培美曲塞(pemetrexed)是一类新型的抗代谢类抗肿瘤药物,它作用于叶酸依赖性代谢途径中的多个酶,为多靶点抗叶酸药物,具有较好的临床应用前景.除FDA批准的适应症恶性胸膜间皮瘤(MPM)和非小细胞肺癌(NSCLC)外,培美曲塞单药或联合化疗对多种消化道肿瘤有明显的治疗作用,尤其对常规方案治疗失败后的患者,培美曲塞给他们带来了新的希望.
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