地塞米松、恩丹西酮预防女性腹腔镜胆囊切除术后恶心呕吐
Anhui Medical and Pharmaceutical Journal(2007)
Abstract
目的比较地塞米松联合恩丹西酮与单独使用恩丹西酮或地塞米松对腹腔镜胆囊切除术(LC)术后恶心呕吐(PONV)的预防作用。方法157例LC手术,全部女性病人,随机分成地塞米松联合恩丹西酮组、恩丹西酮组、地塞米松组及对照组。观察术后24 h内的恶心呕吐发生率。结果联合组、恩丹西酮组、地塞米松组术后24 h内PONV均显著低于对照组(分别为P<0.01,P<0.05,P<0.05)。联合组术后2~12 hPONV显著低于对照组(P<0.01),术后12~24 hPONV显著低于对照组(P<0.01)及恩丹西酮组、地塞米松组(P<0.05)。结论地塞米松联合恩丹西酮能有效预防PONV,疗效优于单独应用恩丹西酮或地塞米松,值得临床使用。
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