DNA甲基化与肿瘤(综述)
Chinese Journal of Urban and Rural Industrial Hygiene(2006)
Abstract
<正>DNA甲基化是哺乳类动物遗传外修饰的重要调控方式,也是脊椎动物DNA惟一的自然化学修饰方式。它在基因突变,基因表达调控,细胞增殖、分化、发育,基因印记等方面起着重要作用,与肿瘤发生和演进有密切联系。大量实验表明,在肿瘤的发生和发展中存在DNA甲基化水平和模式的紊乱,
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