HPA抗原基因频率和不配合率
Chinese Journal of Blood Transfusion(2006)
Abstract
血小板抗原(HPAs)存在于血小板质膜糖蛋白上.24个血小板抗原7个对偶抗原的分子生物学基础已被阐明.HPA抗原基因的某个单核苷酸被替换会导致其编码的单个氨基酸改变而产生不同的HPA免疫原性.已知血小板抗原可诱导同种抗体而导致患者血小板输注无效,输血后紫癜,同种免疫性血小板减少症等[1,2].笔者对100名捐献者的血小板抗原基因进行检测,报告如下.
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