HPLC同时测定注射用赖氨匹林中阿司匹林和水杨酸的含量
Northwest Pharmaceutical Journal(2008)
Abstract
目的采用高效液相色谱法测定注射用赖氨匹林中阿司匹林含量并对其降解产物水杨酸进行控制。方法以十八烷基键合硅胶为填充剂,甲醇-1mL.L-1三乙胺溶液(1∶1,冰醋酸调节pH至3.5)为流动相,检测波长为280nm,以峰面积外标法计算。结果阿司匹林和水杨酸分别在60.34~905.10mg·mL-1和1.20~18.00mg·mL-1质量浓度范围内呈良好的线性关系,其线性相关系数分别为0.9999和0.9999;加样回收率分别为98.76%~99.29%(RSD为0.59%~0.93%)和98.49%~99.69%(RSD为0.80%~1.01%)。结论方法简便、快速,结果准确、可靠。
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