Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature.

Ester Cerdeira Sabino,Lucas Augusto Moysés Franco,Gabriela Venturini,Mariliza Velho Rodrigues,Emanuelle Marques,Lea Campos de Oliveira-da Silva,Larissa Natany Almeida Martins,Ariela Mota Ferreira, Paulo Emílio Clementino Almeida, Felipe Dias Da Silva,Sâmara Fernandes Leite,Maria do Carmo Pereira Nunes,Desiree Sant'Ana Haikal,Claudia Di Lorenzo Oliveira,Clareci Silva Cardoso,Jonathan G Seidman,Christine E Seidman,Juan P Casas,Antonio Luiz Pinho Ribeiro, Jose E Krieger,Alexandre C Pereira

PLoS neglected tropical diseases（2022）

Cited 1|Views19

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Abstract

We suggest that the newly identified locus impacts CCC risk among T cruzi infected individuals through the modulation of a downstream transcriptional and protein signature associated with host-parasite immune response. Functional characterization of the novel risk locus is warranted.

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Key words

chagas cardiomyopathy,new risk locus,chromosome,genome-wide,immune-related

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