Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors
Bioorganic & Medicinal Chemistry Letters(2005)
Abstract
Reductive amination followed by acylation of polymer-linked formyl aryl amidines generate combinatorial libraries of aryl amidines. Potent small molecule naphthylamidine inhibitors (Ki<100nM) of FVIIa/TF have been discovered and their activity against other serine proteases in the coagulation cascade are reported.
MoreTranslated text
Key words
Solid-phase synthesis,Naphthylamidines,Factor VIIa/tissue factor inhibitors
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined