Effects of Hawthorn Leaves Flavonoids Self-emulsifying Granules on Nonalcoholic Fatty Liver in Rats

Objective: To investigate the effect of Hawthorn leaves flavonoids self-emulsifying granules(HLFSG) on non-alcoholic fatty liver disease.Method: Forty rats were randomized into 4 groups and fed high fat diet to induce non-alcoholic fatty liver disease model.Rosiglitazone was as the positive control group.The influence of the HLFSG(50 mg.kg-1) treatments on total cholesterol(TC),triglyceride(TG),low-density lipoprotein-C(LDL-C),high-density lipoprotein-C(HDL-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST),free fatty acid(FFA),superoxide dismutase(SOD),malondialdehyde(MDA) was investigated.Result: Compared with the model group,HLFSG reduced TC,TG,LDL-C,FFA,ALT,AST,MDA significantly(P 0.05,P 0.01),and a significant increase of HDL-C and SOD was observed.Conclusion: HLFSG is beneficial to the treatment of fatty liver through reducing blood lipid and improving the liver functions in rats.