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Inhibitory effects of total saponin extracted from the Aralia Chinesis L against HBV DNA

Cui D

Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases（2011）

Cited 23|Views17
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Abstract
Objective:To evaluate the inhibitory effects of the total saponin extracted from the Aralia Chinesis L.against hepatitis B virus(HBV) in vitro.Methods:HepG 2.2.15 cells as target cell were exposed to different concentrations of total saponin in and lamivudine respectively.PCR was applied to quqntify extracellular HBV DNA.Results:The 50% inhibitory concentration(IC50) of total saponin extracellular HBV DNA was 0.128g/L respectively,and treatment index(TI) was 5.23g/L respectively.Conclusion:The total saponin extracted from Aralia Chinesis L.inhibits HBV replication in vitro to some extent.
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Key words
HBV DNA,Aralia Chinesis L.Saponis,B virus,HepG 2.2.15 cell,hepatitis
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