Identification and quantification of vasoactive intestinal peptide in periradicular lesions.

Chronic periradicular lesions are produced as an inflammatory defense response to a pulpae necrosis process. Neuropeptides may be associated with chronic periradicular lesions due to their abundant innervations ( 1 Torabinejad M Mediators of acute and chronic periradicular lesions. Oral Surg Oral Med Oral Pathol. 1994; 78: 511-520 Abstract Full Text PDF PubMed Scopus (35) Google Scholar ). Vasoactive Intestinal Peptide (VIP) is considered to play an important role in pulpal inflammation. It has also been associated with bone resorption processes stimulating osteoclasts ( 1 Torabinejad M Mediators of acute and chronic periradicular lesions. Oral Surg Oral Med Oral Pathol. 1994; 78: 511-520 Abstract Full Text PDF PubMed Scopus (35) Google Scholar , 2 Konttinen Y Imai S Suda A Neuropeptides and the puzzle of bone remodeling. Acta Orthop Escand. 1996; 67: 632-639 Crossref PubMed Scopus (117) Google Scholar ). However the VIP-role in periradicular disease pathogenesis has not been elucidated ( 1 Torabinejad M Mediators of acute and chronic periradicular lesions. Oral Surg Oral Med Oral Pathol. 1994; 78: 511-520 Abstract Full Text PDF PubMed Scopus (35) Google Scholar ). The purpose of this study was to identify and quantify the VIP-presence in chronic periradicular lesions and correlate it with size lesion.