No endogenous Aβ production in presenilin-deficient fibroblasts
NATURE CELL BIOLOGY(2002)
Abstract
Presenilins (PSs) are involved in the cleavage of integral membrane proteins, such as amyloid-β precursor protein (APP), Notch, ErbB-4 and CD44. The question as to whether or not they are proteases is therefore relevant for the broad field of cell biological research.
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Key words
Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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