Radiosensitization by Overexpression of the Nonphosphorylation Form of IκB-α in Human Glioma Cells

To assess the role of NF-κB in cellular radiosensitivity, we constructed mutated IκB expression plasmids for SY-IκB (with mutations at residues of 32, 36 and 42) expression in human malignant glioma cells (radiosensitive MO54 and radioresistant T98 cells), giving respective cell types referred to as MO54-SY4 and T98-SY14. Both of the clones expressing SY-I κB became radiosensitive, compared with t...