Bis-tetrahydroisoquinoline derivatives: structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline).

Johan Wouters,Kossay Elasaad,Bernadette Norberg,Amaury Graulich,Jean-François Liégeois

European Journal of Medicinal Chemistry（2010）

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摘要

Crystal structure of the three stereoisomers of 1,1′-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

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关键词

Tetrahydroisoquinoline,Potassium channel blockers,Absolute configuration,Crystal structure

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