Asymptomatic Genitourinary Chlamydia-Trachomatis Infection In Women Seropositive For Human-Immunodeficiency-Virus Infection
OBSTETRICS AND GYNECOLOGY(1994)
Abstract
Objective: To evaluate the prevalence of asymptomatic Chlamydia trachomatis genitourinary infection in women with human immunodeficiency virus (HIV) infection.Methods: The prevalence of asymptomatic chlamydial genitourinary infection in HIV-seropositive women was compared with both HIV-seronegative controls and women with unknown HIV status. Chlamydia trachomatis was isolated in cell culture from endocervical and urethral specimens.Results: The prevalence of genitourinary C trachomatis infection among HIV-seropositive women was 18.3% (21 of 115), a rate significantly higher than in both HIV-negative women (11 of 136; P = .016) and controls with unknown HIV status (18 of 326; P = .0001). Crude odds ratios for endocervical and urethral chlamydial infection in HIV-seropositive women compared to HIV-seronegative controls were 2.6 (95% confidence interval [CI] 1.13-6.08) and 3.3 (95% CI 1.15-9.67), respectively. After adjustment for variables related to sexual habits, there was no difference in the risk of cervical C trachomatis infection between HIV-seropositive cases and HIV-seronegative controls (Mantel-Haenszel odds ratio 1.04, 95% CI 0.93-1.14; P =.41). Finally, in HIV-seropositive patients, both the severity of immuno-suppression evaluated by CD4+, CD8+, and total lymphocyte counts and the detection of p24 HIV-related antigen did not correlate with the presence of chlamydial infection.Conclusions: Women infected with HIV are at high risk for asymptomatic genitourinary chlamydial colonization. To prevent a possible ''epidemic'' of pelvic inflammatory disease, appropriate screening programs and therapeutic strategies should be planned.
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Key words
human immunodeficiency virus infection,human immunodeficiency virus,women seropositive
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