Insulin-binding activity of lymphocytes carrying Fcγ receptors in pregnant women with diabetes mellitus

Differences in insulin-binding activity of mononuclear cells and T lymphocytes due to heterogeneity of insulin receptors and effects of the hormonal and metabolic shifts are detected in pregnant women with insulin-dependent diabetes mellitus. In healthy women high insulin-binding activity of mononuclear cells during the third trimester correlates with the content of Fcγ-R + cells, but does not depend on the number of Tγ lymphocyte, despite an increase in their blood count. No correlation between insulin-binding activity of T fraction and the content of Fcγ lymphocytes is detected. The relationship between insulin-binding activity of T lymphocytes and the number of Tγ cells in pregnant diabetics differs from that in healthy women and is different in high and low activity.