ChemInform Abstract: Synthesis, Conformation, and Reactivity of Ethylene-Bridged (2.2.1) Metacyclophanes.

A series of ethylene-bridged [2.2.l]metacyclophanes has been synthesized. It was found out that they can adopt a new type of “inward-folded” conformation depending on the substituent of the one aromatic ring. This conformer exhibited different reactivities from another “inward-folded” one of the non-bridged [2.2.l]metacyclophanes.